Dermal changes in superficial basal cell carcinoma, melanomain situand actinic keratosis and their implications

Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma.

BACKGROUND Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. OBJECTIVES To establish and co...

Actinic Keratosis and Squamous Cell Carcinoma

Actinic keratosis and squamous cell carcinoma.

Actinic keratosis is a common skin disorder in elderly patients with fair complexions. It is caused by exposure to ultraviolet light. If left untreated, actinic keratosis may progress to squamous cell carcinoma. The metastatic potential and prognosis vary with the type and location of the lesion. Several approaches to treatment are available, including local destruction, excisional surgery, Moh...

Actinic Keratosis and Squamous Cell Carcinoma

Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen’s disease

Aldehyde dehydrogenase (ALDH) is an enzyme responsible for oxidizing aldehydes to carbonic acids. ALDH1 is an isoform that is thought to be a stem cell marker as it is highly expressed in the stem cells of various organs. However, its expression in basal cell carcinoma (BCC), actinic keratosis (AK) and Bowen's disease (BD) of the skin has not yet been analyzed. Twenty-five consecutive operative...